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The salts were removed by extraction into 50:25:25 water, butanol, ethyl acetate and dried in vacuo? The compounds of the invention are useful as antibiotics against organisms which are resistant to other tetracycline compounds?

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To induce gene expression in a cell in vitro, the cell is contacted with the substituted tetracycline compound by culturing the cell in a medium containing the substituted tetracycline compound!

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